hi, have another post.

i just want to correct an assumption i made a few posts back regarding pre-op E levels and goserelin.

i just checked my blood tests, taken about seven months after starting goserelin while on 6m EV, and my E level was 546 nmol/l and the T was 1.8 pmol/l. which is a far cry from my presumption! it also fits into everything else that has been suggested.

of course, this does now mean, if i remembered my most recent test correctly, that i'm on way too much


reenie, okay, i wasn't aware of that DVT connection (and, presto), although surely montoring clotting factors keeps an eye on those risks (and doing little leg excercises)? and

Quote:

If you avoid the first pass metabolism you may receive too high a dose.

my blood test was taken a few days after starting the sublingual route. i was reading in a thread on susans.org that you get more E per pill as well, including a sharp E spike in your bloodstream for about five hours after taking the drug. if it means less pills for the same effect though.....

also, it is still my understanding, and running from that article i link too, that patches avoid the first pass too? it's all direct uptake into capillaries after all.

what is this grapefruit thing people talk about? i can't stand the damn stuff myself. now, watermelon...... yum.

Hi all,

Thanks for the info and kind words.

Reenie, thanks I do need to be told from time to time that I'm not paranoid, I do wonder sometimes about the objectivity of the psychiatrist, when I try to explain my concerns, they don't (Probably can't) say that I'm not being paranoid, when I describe the way I feel I'm being treated, its just another way that it interferes in them being able to give a diagnosis, they expect you to be honest and open with them and tell them your woes, but then they aren't honest when they try to wriggle out of the obvious problems with the Health system..... Oh the irony of it...!!!


La_Glitch,

Thanks for that paper, I'm defintiely printing it off and giving a copy to my Doc, and it certainly makes things more clear to me as well.

Why it is that Dr's and GP's seem to think that we as patients can't begin to understand the complexities involved and so dumb down the way they try to tell us things, it amazes me.

Anyway I'm not going to start off again...lol..

Just wanted to reply to peoples replies...


Emma,

I really wish I could get them to start the Goserelin as well, in fact I've been trying to argue for them to do this since the 1st month of starting the Climaval, the problem I have is that as myt psych has taken it upon himself to arrange the hormone treament outside of the nomral pathway, and he isn't really familiar with it at all, then he's being ultra careful, and so is following a strict guideline, and well I feel then that I can't really ask him to deviate from the plan and to start the goserelin first then look at increasing the Climaval, as I feel as though I'm bound to follow the plan as it is, and that if I tread on his toes too much that he'll just pull out alltogether.

The plan as I understand it is, that he intends to prescribe the Climval, starting with a low dose and gradually increase it, monitoring in between increases, until the E level is where it should be, and then to start the Goserelin and do the same with the T levels.

The problem is that wiht his unfamiliarity and his being ultra cautious its causing lomnger than ususal delays, as the tends to monitr for longer than woud normally be the case before increasing the dose.

So between that and the administartive problems of getting blood test results to him in the first place, its really dragging things out even longer than would usually be the case.

Another part of me wonders whether or not its just a way of him buying himself some time, until my referral to GIC has been approved and he can pass me off to them, I really don't know.... thats where the whole paranoia thing comes in then, I don't know if they really are trying to help, or whether they're just buying time to pass the buck....

I want to beleive that my psych really does want to help, but theres always this little doubt niggling away, as I said its a faith thing, and at the moment I've just not got much faith in the medical profession, especailly after literally catching Health Commission Wales out in so many lies...

Oops see there I go again......!!

Anyway thanks all, I really do appreciate you all....!!

Karen

I'm sure you can google grapefruit liver firstpass...

la_glitch wrote:

reenie, okay, i wasn't aware of that DVT connection (and, presto), although surely montoring clotting factors keeps an eye on those risks (and doing little leg excercises)? and

My legs hurt like fuck. I don't do little leg exercises. About 20 miles feels right and once I've got a pace going, they'll go all day.

When they're laid up in bed or on a sofa, they seize. It doesn't take the Wizard of Wedmore to work it out. I take 300mg aspirin to counteract it, but, hey, those were the days...

I tried to explain this to my GP the other day, but she was in too much of a hurry for the next patient. I think I ought to go back and give her a dose of Great Aunt Reen.

"I have only one testicle and instead of it being basically spherical its a long sausage thing from being about 11/12 years old when everything swelled up and got very sore."

sometimes it is a varicocele as this swelling can elongate the testicle and is very common

a collection of varicose veins of the spermatic cord (the rope-like structure that suspends each testicle). They occur in about 15% of the population. More than 90% occur on the left, 5% on the right and the rest are bilateral. Varicoceles are due to a defective valve in the vein that drains blood from the testicle.

They fill by gravity and therefore are not detectable while recumbent but apparent when upright. On examination, the lesion feels like a bag of worms. Small varicoceles may only be detected by imaging studies such as ultrasound. A varicocele that does not disappear when lying down may indicate a tumor in the abdomen (but this is quite unusual). Varicoceles are generally painless. Often men present to the doctor with pain in the testicle and the varicocele is discovered at that time. The pain is very rarely due to the vairicoele and usually due to prostatitis (an inflammation of the prostate gland). In other words, the varicocele is an incidental and unrelated condition. Varcioceles may cause an infertility problem manifest by lower sperm counts and increased numbers of immature sperm in the semen on analysis. However, the majority of men with varicoceles do NOT have infertility. Of men who have abnormal semen analyses and varicoceles, in about 70% of them, the 2 are related and fixing the varicolele often will improve their fertility. If a teenager or young man with a varicocele has a smaller than normal testicles on that side, there is an increase risk of infertility and many urologists consider this an indication to fix the varicocele surgically.

Source Arthur Goldstein, M.D.

_________________
Man [...] must count no one but himself; that he is alone, abandoned on earth in the midst of his infinite responsibilities, without help, with no other aim than the one he sets himself, with no other destiny than the one he forges for himself on this earth." (Jean Paul Sartre, 1943)